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Implementation research is the scientific study of the determinants, processes and outcomes of implementation. Whilst there is an increasing body of implementation research, we are not advancing knowledge as efficiently as we could. There is considerable waste in implementation research (as in all other areas of health research) particularly due to failures to ask the right research questions, failures to use current available evidence when planning future research and failures to maximise the informativeness of syntheses of implementation programs. The seminar will discuss these issues and offer suggestions to enhance value and reduce waste.